Ceftriaxone
Community-acquired pneumonia, Meningitis, UTI/pyelonephritis, Gonorrhea, Spontaneous bacterial peritonitis
Indications
- Community-acquired pneumonia
- Meningitis
- UTI/pyelonephritis
- Gonorrhea
- Spontaneous bacterial peritonitis
Adult dosing
- standard: dose: 1; unit: g; route: IV/IM; interval: q24h; fixed: true; meningitis: dose: 2; unit: g; route: IV; interval: q12h; fixed: true; gonorrhea: dose: 500; unit: mg; route: IM; interval: single dose; fixed: true
Pediatric dosing
- standard: dose: 50; unit: mg/kg; maxDose: 2000; route: IV/IM; interval: q24h; weightBased: true; meningitis: dose: 100; unit: mg/kg/day; maxDose: 4000; route: IV divided q12h; weightBased: true; pedNote: Divide into q12h dosing for meningitis
Contraindications
- Cephalosporin allergy
- Neonates with hyperbilirubinemia or receiving calcium-containing IV solutions
Clinical pearls
- Do NOT co-infuse with calcium-containing solutions in neonates — fatal precipitation
- Excellent CSF penetration — first-line for bacterial meningitis (with vancomycin)
- Once daily dosing makes it ideal for outpatient parenteral antibiotic therapy (OPAT)
Source and review
- IDSA Guidelines; Sanford Guide. Last reviewed: 2024-11-01