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Dopamine

Symptomatic bradycardia, Cardiogenic shock, Septic shock (second-line)

Indications

  • Symptomatic bradycardia
  • Cardiogenic shock
  • Septic shock (second-line)

Adult dosing

  • low dose: dose: 2; maxDose: 5; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65; moderate dose: dose: 5; maxDose: 10; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65; high dose: dose: 10; maxDose: 20; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65

Pediatric dosing

  • drip: dose: 2; maxDose: 20; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65

Contraindications

  • Pheochromocytoma
  • Uncorrected tachyarrhythmias

Clinical pearls

  • Low dose (2-5 mcg/kg/min): dopaminergic effects — renal/mesenteric vasodilation
  • Moderate dose (5-10): beta-1 effects — increased cardiac output
  • High dose (>10): alpha effects — vasoconstriction, increased SVR
  • More arrhythmogenic than norepinephrine — not first-line for septic shock

Source and review

  • ACLS Guidelines 2020, AHA. Last reviewed: 2024-10-01