Enoxaparin
DVT/PE treatment, ACS adjunct, VTE prophylaxis
Indications
- DVT/PE treatment
- ACS adjunct
- VTE prophylaxis
Adult dosing
- treatment: dose: 1; unit: mg/kg; route: SC; interval: q12h; weightBased: true; maxDose: 150; maxDoseAbsolute: true; acs: dose: 1; unit: mg/kg; route: SC; interval: q12h (with initial 30mg IV bolus); weightBased: true; maxDose: 150; maxDoseAbsolute: true; prophylaxis: dose: 40; unit: mg SC daily; route: SC; fixed: true
Pediatric dosing
- treatment: dose: 1; unit: mg/kg; route: SC; interval: q12h; weightBased: true
Contraindications
- Active major bleeding
- HIT history
- CrCl <15
Clinical pearls
- Dose reduction required in renal impairment — CrCl <30 use q24h dosing
- Anti-Xa level for monitoring if needed (obese, renal impairment, pregnancy)
- Partial reversal with protamine — only ~60% effective
- Do NOT interchange with other LMWHs — not equivalent
Source and review
- ACCP Guidelines 2016; AHA/ACC NSTEMI Guidelines. Last reviewed: 2024-11-01