Epinephrine
Cardiac arrest, Anaphylaxis, Septic shock (vasopressor)
Indications
- Cardiac arrest
- Anaphylaxis
- Septic shock (vasopressor)
Adult dosing
- cardiac arrest: dose: 1; unit: mg; route: IV/IO; interval: q3-5min; fixed: true; anaphylaxis: dose: 0.3; unit: mg; route: IM; site: lateral thigh; fixed: true; drip: dose: 0.1; maxDose: 0.5; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65 or clinical response
Pediatric dosing
- cardiac arrest: dose: 0.01; unit: mg/kg; maxDose: 1; maxDoseAbsolute: true; route: IV/IO; interval: q3-5min; weightBased: true; anaphylaxis: dose: 0.01; unit: mg/kg; maxDose: 0.5; maxDoseAbsolute: true; route: IM lateral thigh; weightBased: true; drip: dose: 0.1; maxDose: 1; unit: mcg/kg/min; route: IV; weightBased: true; titrationTarget: Titrate to MAP ≥65 or clinical response
Clinical pearls
- Cardiac arrest: 1mg IV/IO q3-5min — no maximum in arrest
- Anaphylaxis: IM thigh preferred over IV unless in shock
- Drip: titrate to MAP >65; expect tachycardia
Source and review
- ACLS Guidelines 2020, AHA. Last reviewed: 2024-11-01