MASCC Score

Risk stratification in febrile neutropenia

Indication

id: burden; label: Burden of illness; type: options; options: label: No/mild symptoms; value: 5; label: Moderate symptoms; value: 3; label: Severe symptoms (moribund); value: 0
id: no_hypotension; label: No hypotension (SBP ≥90); type: yesno; points: 5
id: no_copd; label: No COPD; type: yesno; points: 4
id: solid_tumor; label: Solid tumor or heme malignancy with no prior fungal infection; type: yesno; points: 4
id: no_dehydration; label: No dehydration requiring IV fluids; type: yesno; points: 3
id: outpatient; label: Outpatient at onset of fever; type: yesno; points: 3
id: age_lt60; label: Age < 60; type: yesno; points: 2

function(score) { if (score >= 21) return { risk: score + '/26', tier: 'Low Risk', action: 'Low risk for complications. Consider outpatient management with oral antibiotics.', color: 'green' }; return { risk: score + '/26', tier: 'High Risk', action: 'High risk for complications. Inpatient IV antibiotics required.', color: 'red' }; }

MASCC ≥21: low risk — may be eligible for outpatient oral antibiotics (cipro + amox-clav)
MASCC <21: high risk — admit for IV antibiotics (cefepime, meropenem, or pip-tazo)
Maximum possible score is 26
Must have reliable follow-up and ability to take oral meds for outpatient management

Klastersky et al., JCO 2000; IDSA Febrile Neutropenia Guidelines. Last reviewed: 2024-10-15