SOFA Score

Quantify organ dysfunction in sepsis. Required for the Sepsis-3 definition. Used for ICU prognosis and tracking response to treatment.

Indication

Quantify organ dysfunction in sepsis. Required for the Sepsis-3 definition. Used for ICU prognosis and tracking response to treatment.

id: pf; label: PaO2/FiO2 ratio; type: options; options: value: 0; label: ≥400; value: 1; label: 300–399; value: 2; label: 200–299; value: 3; label: 100–199 (on respiratory support); value: 4; label: <100 (on respiratory support)
id: platelets; label: Platelets (×10³/µL); type: options; options: value: 0; label: ≥150; value: 1; label: 100–149; value: 2; label: 50–99; value: 3; label: 20–49; value: 4; label: <20
id: bilirubin; label: Bilirubin (mg/dL); type: options; options: value: 0; label: <1.2; value: 1; label: 1.2–1.9; value: 2; label: 2.0–5.9; value: 3; label: 6.0–11.9; value: 4; label: ≥12.0
id: cardiovascular; label: Cardiovascular; type: options; options: value: 0; label: No hypotension; value: 1; label: MAP <70 mmHg; value: 2; label: Dopamine ≤5 or dobutamine (any); value: 3; label: Dopamine >5 or epi ≤0.1 or norepi ≤0.1; value: 4; label: Dopamine >15 or epi >0.1 or norepi >0.1
id: gcs; label: Glasgow Coma Scale; type: options; options: value: 0; label: GCS 15; value: 1; label: GCS 13–14; value: 2; label: GCS 10–12; value: 3; label: GCS 6–9; value: 4; label: GCS <6
id: renal; label: Creatinine (mg/dL) / Urine output; type: options; options: value: 0; label: <1.2; value: 1; label: 1.2–1.9; value: 2; label: 2.0–3.4; value: 3; label: 3.5–4.9 or UO <500 mL/day; value: 4; label: ≥5.0 or UO <200 mL/day

function(score) { if (score <= 6) return { risk: score + '/24', tier: 'Low Mortality (<10%)', action: 'Limited organ dysfunction. Continue source control and supportive care. Track delta SOFA.', color: 'green' }; if (score <= 9) return { risk: score + '/24', tier: 'Moderate Mortality (~15\u201320%)', action: 'Significant organ dysfunction. Escalate resuscitation and monitoring; ICU-level care.', color: 'yellow' }; if (score <= 12) return { risk: score + '/24', tier: 'High Mortality (~40\u201350%)', action: 'Multi-organ dysfunction. Aggressive ICU management; reassess source control.', color: 'red' }; if (score <= 14) return { risk: score + '/24', tier: 'Very High Mortality (~50\u201360%)', action: 'Severe multi-organ failure. Maximal support; discuss goals of care.', color: 'red' }; return { risk: score + '/24', tier: 'Critical Mortality (>80%)', action: 'Overwhelming organ failure. Maximal support and early goals-of-care discussion.', color: 'red' }; }

Delta SOFA (change from baseline) is more prognostically important than the absolute score
SOFA rise ≥2 from baseline + suspected infection = sepsis by the Sepsis-3 definition
The respiratory component (P/F ratio) is most commonly the first to become abnormal
Assume a baseline SOFA of 0 in patients not known to have pre-existing organ dysfunction